Arcana provide you with powerful buffs in Vampire Crawlers. When setting out for a run, you can choose one Arcana to equip (though you may find others in purple chests during your dungeon crawl).
Relics are special items you can find in Vampire Crawlers. Each time you obtain a new Relic, you unlock new game mechanics. The first of these is the Combo Stack, which you find during the tutorial.
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